Prof. Cheong-Weon ChoKorea
Chungnam National University
| 2006/03 to present | | Chungnam National University |
| 1993 - 1996 | | Chonnam National University |
| 1997 - 2000 | | Korea Research Institute of Bioscience and Biotechnology |
| 2000 - 2002 | | University of Colorado Health Science Center |
| 2002 - 2006 | | CJ Research Institute |
Drug delivery systems, dosage forms, nanoparticles, microneedle
Controlled Release of Ticagrelor via SMEDDS–Alginate Beads with pH-Responsive Behavior
TBA TBA
Biomedical Materials and Precision Medicine/TBA
Formulation is the process of developing a final dosage form by optimally combining active pharmaceutical ingredients and excipients to ensure the safe and effective use of a drug. It involves the physical and chemical integration of single or multiple components to design a system in which the drug can act efficiently within the human body. Proper formulation design maximizes the pharmacological efficacy of the drug, maintains its physicochemical stability, and provides a dosage form that is convenient for patient administration. Ticagrelor (TCG) is a poorly soluble and permeable anti-platelet agent with limited oral bioavailability. To overcome this limitation, a novel oral formulation such as TCG-loaded self-microemulsifying drug delivery system (SMEDDS) showing rapid and improved absorption was developed. In this study, we aimed to control the release of TCG via the formation of TCG-loaded SMEDDS-alginate beads (TSAB) through combining TCG-loaded SMEDDS (TCG-SM) and pH sensitive alginate beads. TSAB exhibited pH-responsive release, with attenuated initial drug release in acidic buffer (pH 1.2) and enhanced release in neutral buffer of pH 6.8, leading to enhanced gastrointestinal absorption.