Speakers

The ineffective enhanced permeability-retention (EPR) effect-based accumulation of conventional nanotherapeutics in tumour tissue may be circumvented using stimulus-responsive ultrasmall nano-constructs (SRusNC) that exhibit high tumour tissue penetration traits (owing to their ultrasmall size i.e. < 5nm) and generate tumour annihilating heat or cytotoxic free radicals at near tumour vicinity upon exposure to suitable external stimulation (e.g. ultrasound). Nevertheless, these SRusNC also faces limitations of swift blood and renal clearance due to their ultrasmall particle size. In this talk, focus will be placed on introducing ultrasound-regulated clustering as potential strategy to prolong the bioavailability of SRusNC but yet at the same time to retain their high tumour penetrating properties, and to share the recent experience of our laboratory the use of such strategy on SRusNC, the limitations encountered and future perspectives of ultrasound-regulated SRusNC clusters as the next generation nanomedicine.